Disodium clodronate tetrahydrate

Clodronic acid(INN) orclodronate disodium(USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures,hyperparathyroidism,hypercalcemia in malignancy,multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β,IL-6, and TNF-alfa.(In Vitro):Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission .Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence .Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis.(In Vivo):Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition.Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition .