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Dutasteride

SKU: orb1308434

Description

Dutasteride

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number164656-23-9
MW528.53
Purity99.68%
FormulaC27H30F6N2O2
SMILESC[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]
TargetReductase,Apoptosis
SolubilityDMSO:44.5 mg/mL (84.2 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:2.5 mg/mL (4.73 mM);Ethanol:6 mg/mL (11.35 mM)

Bioactivity

In Vivo
Dutasteride effectively inhibits Type I 5AR IC50 6 nM) and Type II 5AR IC50 7 nM). In LNCaP cells IC50 1 μM), it suppresses DHT-induced PSA secretion and proliferation, and competes for androgen receptor (AR) binding IC50 1.5 μM). Additionally, dutasteride reduces cell viability and proliferation In both androgen-responsive (LNCaP) and androgen-nonresponsive (DU145) human prostate cancer (PCa) cell lines.
In Vitro
In healthy Male rats, daily treatment with Dutasteride (10 mg/kg) resulted in a prostate size that was hal the size of that in control rats.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Dutasteride, Apoptosis, Avodart, 5α-reductase, 5-α reductase, 5 alpha Reductase, GI 198745, GI198745, GI-198745, GG745, GG-745, GG 745, inhibit, Inhibitor

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Quality Guarantee

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Key Properties

No computed properties available.

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Dutasteride (orb1308434)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 100.00
25 mg
$ 120.00
50 mg
$ 150.00
100 mg
$ 210.00
200 mg
$ 270.00
500 mg
$ 420.00
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