Edoxaban

SKU: orb1305585

Description

Edoxaban (Lixiana, DU-176b) is a potent, selective, and orally active direct inhibitor of coagulation factor Xa (FXa), exhibiting over 10,000-fold selectivity versus related serine proteases. This small molecule anticoagulant is widely used in research for investigating thrombosis, stroke prevention, and its pharmacological effects in both in vitro enzymatic assays and in vivo disease models.

Research Area

Metabolism Research, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	480449-70-5
MW	548.06
Purity	99.71% (May vary between batches)
Formula	C₂₄H₃₀ClN₇O₄S
SMILES	N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3
Target	Thrombin,Factor Xa
Solubility	DMSO:2.74 mg/mL (5 mM)

Bioactivity

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In Vivo

Edoxaban (DU-176b; 0.5-12.5 mg/kg; oral administration; Wistar rats) inhibits thrombus formation in rat thrombosis models in a dose-dependent manner . Animal Model: Wistar rats (210-240 g) with venous stasis thrombosis model Dosage: 0.5 mg/kg, 2.5 mg/kg, 12.5 mg/kg Administration: Oral administration Result: Dose-dependently inhibited thrombus formation in rat thrombosis models.

In Vitro

Edoxaban (DU-176b) also inhibits rat, cynomolgus monkey and rabbit FXa with K i values of 6.90 nM, 0.715 nM and 0.457 nM, respectively . Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) of human plasma are prolonged by Edoxaban (DU-176b) in a concentration-dependent way, doubling PT and APTT at 0.256 and 0.508 μM, respectively. The double clotting time (CT2) for TT, however, was much higher (4.95 μM), reflecting its anti-thrombin activity. Thrombin-induced platelet aggregation is inhibited by a high concentration of Edoxaban (DU-176b) (IC 50 : 2.90 μM), reflecting its weak anti-thrombin activity . Edoxaban is minimally metabolized (,4%) by the cytochrome P450 system (CYP3A4) and is a substrate for P-glycoprotein .

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Lixiana, Edoxaban, FactorXa, Factor Xa, Thrombin

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Compound Identifiers

PubChem CID

10280735 ↗

Key Properties

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No computed properties available.

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Edoxaban (orb1305585)

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CAS Number:	480449-71-6
MW:	720.259120000001
Formula:	C₂₄H₃₀N₇O₄SCL.C₇H₈O₃S

Purity:	99.91%
CAS Number:	1229194-11-9
MW:	738.27
Formula:	C₃₁H₄₀ClN₇O₈S₂

CAS Number:	480452-37-7
MW:	367.83
Formula:	C₁₆H₂₂ClN₅O₃

CAS Number:	1255529-24-8
MW:	548.06
Formula:	C₂₄H₃₀ClN₇O₄S

CAS Number:	1304701-57-2
MW:	554.09
Formula:	C₂₄H₂₄D₆ClN₇O₄S

Edoxaban

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Edoxaban (orb1305585)

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