Enoblituzumab Antibody

SKU: orb1941149

Description

Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung cancer (NSCLC).

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1353485-38-7
MW	145.81 kDa
Purity	96.7% (SDS-PAGE); 98.5% (SEC-HPLC)
Target	B7,Immunology/Inflammation related,Others

Bioactivity

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In Vivo

In mice (mCD16-/-hCD16A+) with murine CD16 gene knocked out and transgenic for human CD16A-158F, enoblituzumab (5 mg/kg; i.v.; single dose) exhibits an estimated half-life of 249 hours with a Cmax of 43 mg/mL. Exhibiting potent antitumor activity in xenograft mice models of renal cell and bladder carcinoma expressing B7-H3, enoblituzumab (0.1-10 mg/kg; i.v.; once weekly; 5 weeks) shows this effect.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Enoblituzumab, MGA271, MGA-271, MGA 271, TJ 271, TJ271, TJ-271

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Gene Symbol

B7,Immunology/Inflammation related,Others

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