Enoxacin

SKU: orb1310354

Description

Enoxacin is a 6-fluoroquinolone antibiotic structurally derived from nalidixic acid. It is widely used in research for its antibacterial activity in vitro and has been employed in studies exploring DNA gyrase inhibition and bacterial infection models in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	74011-58-8
MW	320.32
Purity	98.68%
Formula	C₁₅H₁₇FN₄O₃
SMILES	C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(N2)N3CCNCC3
Target	DNA/RNA Synthesis,Topoisomerase,Antibacterial,MicroRNA,Antibiotic
Solubility	DMSO:60 mg/mL (187.31 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vitro

Enoxacin, a fluoroquinolone used as an antibacterial compound, enhances the production of miRNAs with tumor suppressor functions by binding to the miRNA biosynthesis protein TAR RNA-binding protein 2 (TRBP). Enoxacin binds to the DNA active site and alters the breakage/reunion activity of the enzyme. Enoxacin stimulates cleavage of both relaxed and supercoiled forms of DNA in the absence of ATP, whereas CcdB induces cleavage only after many cycles of ATP-dependent breakage and reunion. Enoxacin dose dependently reduces the number of osteoclasts differentiating in mouse marrow cultures stimulated with 1,25-dihydroxyvitamin D(3), as well as markers of osteoclast activity, and the number of resorption lacunae formed on bone slices. Enoxacin inhibits osteoclast formation at concentrations where osteoblast formation is not altered. Enoxacin dose-dependently reduces the number of multinuclear cells expressing tartrate-resistant acid phosphatase (TRAP) activity produced by RANK-L-stimulated osteoclast precursors. Enoxacin directly inhibits osteoclast formation without affecting cell viability by a novel mechanism that involves changes in posttranslational processing and trafficking of several proteins with known roles in osteoclast function. Enoxacin is able to decrease cell viability, induce apoptosis, cause cell cycle arrest, and inhibit the invasiveness of prostate cancer (PCa) cell lines. Enoxacin is also effective in restoring the global expression of miRNAs in prostate cancer (PCa) cell lines.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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siRNA, TAR-RNA, topoisomerase, Topo IV, Topo II, RNASynthesis, RNA Synthesis, TRBP, CI919, CI-919, CI 919, DNA, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, Antibiotic, AT2266, AT-2266, AT 2266, Bacterial, inhibit, mRNA, NSC 629661, NSC629661, NSC-629661, Pd107779, miRNA, MicroRNA, Inhibitor, Enoxacin, gram-negative, gram-positive, gyrase

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Compound Identifiers

PubChem CID

3229 ↗

Key Properties

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No computed properties available.

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Enoxacin (orb1310354)

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MW:	364.83
Formula:	C₁₅H₁₀D₈ClFN₄O₃

Purity:	99.86%
CAS Number:	84294-96-2
MW:	347.34
Formula:	C₁₅H₁₇FN₄O₃·3/2H₂O

CAS Number:	84294-96-2
MW:	347.34
Formula:	C₁₅H₁₇FN₄O₃·3/2H₂O

Purity:	>98% (HPLC)
CAS Number:	84294-96-2
MW:	347.34
Formula:	C₁₅H₁₇FN₄O₃·3/2H₂O

Purity:	>98% (HPLC)
CAS Number:	74011-58-8
MW:	320.32
Formula:	C₁₅H₁₇FN₄O₃

Enoxacin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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