Eravacycline dihydrochloride

SKU: orb1709742

Description

Eravacycline dihydrochloride (TP-434-046) is a broad-spectrum, potent antibacterial agent effective against E. coli strains, with MIC values ranging from 0.125 to 0.25 mg/L. This fluorocycline tetracycline analog is a valuable research tool for investigating novel antibiotics in both in vitro and in vivo models of bacterial infection.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	1334714-66-7
MW	631.48
Purity	>99.99% (May vary between batches)
Formula	C₂₇H₃₃Cl₂FN₄O₈
SMILES	Cl.Cl.[H][C@@]12Cc3c(F)cc(NC(=O)CN4CCCC4)c(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
Target	Antibacterial
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.92 mM);H2O:45 mg/mL (71.26 mM);DMSO:135 mg/mL (213.78 mM)

Bioactivity

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In Vivo

Eravacycline(3.125-50 mg/kg) shows mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint of 27.97 and 32.60. In mouse septicemia models, Eravacycline is efficacious against Staphylococcus aureus and demonstrates 50% protective dose values of ≤1 mg/kg. The PD50s are 1.2-4.4 mg/kg against Escherichia coli isolates.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Antibacterial, Eravacycline, Eravacycline Dihydrochloride, TP 434, TP 434 Dihydrochloride, TP-434-046, TP434, TP-434, TP434 Dihydrochloride, TP-434 Dihydrochloride, TP-434 dihydrochloride

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Compound Identifiers

PubChem CID

56951485 ↗

Key Properties

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No computed properties available.

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