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Fanapanel

SKU: orb1708171

Description

Fanapanel (ZK200775) is a quinoxalinedione-based compound that acts as a potent and competitive AMPA receptor antagonist. It is a valuable research tool for investigating cerebrovascular diseases, such as stroke, in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number161605-73-8
MW409.25
FormulaC14H15F3N3O6P
SMILESO=C1NC=2C=C(C(=CC2N(C1=O)CP(=O)(O)O)N3CCOCC3)C(F)(F)F
TargetiGluR
SolubilityDMSO:1 mg/mL (2.44 mM)

Bioactivity

Target IC50
AMPA/kainate receptor:21 nM
In Vivo
In the permanent MCAO model, intravenous infusion of Fanapanel (0.1-10 mg/kg/h for 6 hours) reduced the infarct volume by 24-34%, and it remained effective even when administered 1-5 hours later (reducing infarct volume by 20-30%). In the transient MCAO model, immediate or delayed injection of Fanapanel (0.01-3 mg/kg/h) 2 hours after reperfusion reduced the infarct volume by approximately 45%. In the gerbil global cerebral ischemia model, Fanapanel protected the hippocampal CA1 region. Long-term toxicity studies (rats 6 mg/kg/h, dogs 0.2 mg/kg/h for 4 weeks) did not show renal or neurotoxicity .
In Vitro
In rat cortical slice experiments, the inhibitory effect of Fanapanel on AMPA receptors was measured to assess its activity. The Results showed that the IC50 value for Fanapanel's inhibition of AMPA-induced currents was 21 nM, demonstrating strong neuroprotective and anticonvulsant effects .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ZK 200775, ZK200775, ZK-200775, MPQX, Fanapanel, AMPAR

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Key Properties

No computed properties available.

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Protocol Information

Fanapanel (orb1708171)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

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2 mg
$ 110.00
DispatchUsually dispatched within 5-10 working days
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