FGA139

SKU: orb3027480

Description

FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

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Key Properties

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Formula	C₄₈H₅₈BF₂N₇O₅
Target	TNF,Cysteine Protease,NO Synthase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

TNF,Cysteine Protease,NO Synthase

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FGA139 (orb3027480)

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FGA139

Description

Research Area

Images & Validation

Key Properties

Storage & Handling

Quality Guarantee

Quick Database Links

Documents Download

Request a Document

Protocol Information

FGA139 (orb3027480)

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