FGI-106 tetrahydrochloride

SKU: orb1309675

Description

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	1149348-10-6
MW	604.48
Purity	98.98%
Formula	C₂₈H₄₂Cl₄N₆
SMILES	Cl.Cl.Cl.Cl.CN(C)CCCNc1cc(C)nc2c1ccc1c2ccc2c(NCCCN(C)C)cc(C)nc12
Target	Virus Protease,Anti-infection,HIV Protease,HCV Protease,Influenza Virus
Solubility	DMSO:7.5 mg/mL (12.41 mM)

Bioactivity

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Target IC50	HCV: 200 nM \|Rift Valley virus: 800 nM \|HIV-1:150 nM \|DENV: 400-900 nM \|EBOV:（EC50）100 nM
In Vivo	FGI-106 treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
In Vitro	In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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VirusProtease, Virus Protease, replication, Rift Valley virus, tetrahydrochloride, antiviral, broad-spectrum, Ebola, Ebola virus, EBOV, Dengue Fever virus, inhibit, InfluenzaVirus, Influenza Virus, pathogens, Inhibitor, HIV, HIVProtease, HIV-1, HIV Protease, HCV, HCV Protease, HCVProtease, hemorrhagic, Hepatitis C virus, lethal, Human immunodeficiency virus, FGI 106, FGI 106 Tetrahydrochloride, FGI 106 tetrahydrochloride, FGI106, FGI-106, FGI106 tetrahydrochloride, FGI106 Tetrahydrochloride, FGI-106 tetrahydrochloride, FGI-106 Tetrahydrochloride, fever

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Compound Identifiers

PubChem CID

44128993 ↗

Key Properties

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No computed properties available.

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