Flanvotumab Antibody

SKU: orb1980436

Description

Flanvotumab (IMC-20D7S) is a humanized anti-TYRP1 monoclonal antibody. It demonstrates significant antitumor activity primarily through antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer cells. This mechanism supports its research application in studying melanoma both in vitro and in vivo.

Research Area

Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	1188277-05-5
MW	145.42 kDa
Purity	> 95%
Target	Tyrosinase

Bioactivity

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In Vitro	Flanvotumab is developed based on TA99, a mouse IgG2a monoclonal antibody against TYRP1. TA99 is positioned in subcutaneous melanoma xenografts and inhibits the growth of syngeneic tumors in preclinical models.The antitumor effect of TA99 relies on the presence of intact antibodies, Fc receptors, and natural killer (NK) cells. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tyrosinase, 20D7S, IMC 20D7S

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Gene Symbol

Tyrosinase

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