Fosphenytoin sodium

SKU: orb1220861

Description

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker.(In Vivo):Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).

Images & Validation

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Key Properties

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CAS Number	92134-98-0
MW	406.24
Purity	>98% (HPLC)
Formula	C₁₆H₁₃N₂Na₂O₆P
SMILES	[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1
Target	Sodium Channel
Solubility	H2O:100 mg/mL (246.16 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ACC-9653

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Gene Symbol

Sodium Channel

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