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Ganetespib

SKU: orb1305731

Description

Ganetespib

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number888216-25-9
MW364.4
Purity99.95%
FormulaC20H20N4O3
SMILESCC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3n(C)ccc3c2)c(O)cc1O
TargetHSP,Apoptosis,HIF
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:40 mg/mL (109.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
HSP90:4 nM
In Vivo
Ganetespib was able to exhibit cytotoxicity at the nanomolar level, inhibiting cell proliferation while inducing apoptosis in a variety of human anti-receptor tyrosine kinase inhibitor and tapepermycin-resistant cancer cell lines. In MG63 cell line (IC50=43 nM), Ganetespib inhibited cell growth. In C2 (IC50=19 nM) and BR canine malignant mast cells (IC50=4 nM), Ganetespib induced apoptosis.
In Vitro
Ganetespib was able to exhibit cytotoxicity at the nanomolar level, inhibiting cell proliferation while inducing apoptosis in a variety of human anti-receptor tyrosine kinase inhibitor and tapepermycin-resistant cancer cell lines. In MG63 cell line (IC50=43 nM), Ganetespib inhibited cell growth. In C2 (IC50=19 nM) and BR canine malignant mast cells (IC50=4 nM), Ganetespib induced apoptosis.
Cell Research
A total of 1.5 × 103 OSA cells are seeded in 96-well plates in 10% serum-containing complete medium and incubated overnight to determine the 50% inhibitory concentrations. Plates are, harvested at day 5 following 0.001, 0.005, 0.01, 0.05, 0.1, 0.5 and 1 μM Ganetespib, treatment and analyzed. Fluorescence measurements are made using a plate reader with excitation at 485 nm and emission detection at 530 nm. Relative cell number is calculated as a percentage of the control wells: absorbance of sample/absorbance of DMSO treated cells × 100.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, inhibit, HSP, HSP90, Ganetespib, Inhibitor, HIF-1α, Heat shock proteins, STA 9090, STA9090, STA-9090

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Quality Guarantee

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Key Properties

No computed properties available.

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Ganetespib (orb1305731)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 130.00
25 mg
$ 180.00
50 mg
$ 210.00
100 mg
$ 310.00
200 mg
$ 490.00
500 mg
$ 780.00
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