GGFG-PAB-Exatecan TFA

SKU: orb2814487

Description

GGFG-PAB-Exatecan TFA is a drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis, combining the potent topoisomerase I inhibitor Exatecan with a cleavable GGFG-PAB linker. This construct is utilized in research for developing targeted cancer therapies and has been evaluated in both in vitro and in vivo preclinical studies.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Molecular Biology

Images & Validation

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Key Properties

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MW	1016.95
Formula	C₄₉H₄₈F₄N₈O₁₂
SMILES	NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Target	Topoisomerase,Drug-Linker Conjugates for ADC

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Topoisomerase,Drug-Linker Conjugates for ADC

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