Givinostat hydrochloride monohydrate

SKU: orb1300909

Description

Givinostat hydrochloride monohydrate (ITF2357) is a histone deacetylase (HDAC) inhibitor. It is used in biochemical and cellular research to study epigenetic regulation and has been investigated in preclinical models for conditions such as Duchenne muscular dystrophy and inflammatory diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Images & Validation

−

Key Properties

−

CAS Number	732302-99-7
MW	475.97
Purity	99.51% (May vary between batches)
Formula	C₂₄H₂₇N₃O₄·HCl·H₂O
SMILES	O.Cl.CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
Target	HDAC
Solubility	DMSO:88 mg/mL (184.89 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.93 mM);Ethanol:1 mg/mL (2.1 mM)

Bioactivity

−

Target IC50	HDAC8 (human):854 nM\|HD1-A:16 nM\|HDAC7 (human):524 nM\|HDAC5 (human):532 nM\|HDAC11 (human):292 nM\|HDAC2 (human):325 nM\|HDAC4 (human):1059 nM\|HD2:10 nM\|HDAC9 (human):541 nM\|HDAC3 (human):157 nM\|HDAC6 (human):315 nM\|HD1-B:7.5 nM\|HDAC1 (human):198 nM\|HDAC10 (human):340 nM Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

ITF-2357 hydrochloride monohydrate, Gavinostat hydrochloride monohydrate, Gavinostat Hydrochloride, HDAC, HD2, HD1-B, HD1-A

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

9804991 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols