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GL392

SKU: orb2944591

Description

GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.

Research Area

Cell Biology

Images & Validation

Key Properties

MW1042.6
FormulaC55H52ClN13O5S
SMILESO=C(CCC(OCCN1CCN(C2=CC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=NC(C)=N2)CC1)=O)OCC(N5)(C)NC6=CC=CC(C6=C5C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10
TargetApoptosis

Storage & Handling

Storage-20°C
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

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Protocol Information

GL392 (orb2944591)

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