Glenzocimab Antibody

SKU: orb1944777

Description

Glenzocimab (ACT017) is a humanized anti-GPVI monoclonal antibody Fab fragment. It inhibits collagen-induced platelet aggregation and has been investigated in preclinical stroke models and clinical studies for acute ischemic stroke and cerebral thrombosis.

Images & Validation

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Key Properties

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CAS Number	2101829-58-5
MW	48.29 kDa
Purity	100% (SEC-HPLC)
Target	Others

Bioactivity

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Target IC50	GPVI-Fc:1.37 μg/mL
In Vivo	Glenzocimab ( 1-8 mg / kg ; i.v. ) inhibited collagen-induced platelet aggregation in cynomolgus monkeys [ 2 ].
In Vitro	Inhibited the binding of GPVI-Fc to collagen immobilized on microtiter plates, glenzocimab (0-100,000 ng/mL) demonstrated an IC50 of 1.37 μg/mL.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Glenzocimab, ACT017, ACT-017, ACT 017

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