Cart summary

You have no items in your shopping cart.

Glibornuride

SKU: orb1308273

Description

Glibornuride is a potent ATP-sensitive potassium (KATP) channel blocker, as evidenced by its inhibition of high-affinity [³H]-glibenclamide binding. This sulfonylurea is used in research to study KATP channel function and insulin secretion mechanisms in pancreatic beta cells, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number26944-48-9
MW366.48
Purity99.50% (May vary between batches)
FormulaC18H26N2O4S
SMILES[H][C@@]12CC[C@@](C)([C@@H](O)[C@H]1NC(=O)NS(=O)(=O)c1ccc(C)cc1)C2(C)C
TargetPotassium Channel
SolubilityDMSO:250 mg/mL (682.17 mM)

Bioactivity

Target IC50
K+-ATP channel:5.75 (pKi)
In Vivo
Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) increases body weight and liver lipid peroxidation levels, while reducing serum uric acid levels in diabetic Swiss albino rats .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Streptozotocin, PotassiumChannel, Potassium Channel, sensitive, Inhibitor, KATP channel, inhibit, KcsA, K channel, Parsley, Glibornuride, blocker ATP, Antidiabetic, ATP-sensitive potassium (KATP) channels
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Glibornuride (orb1308273)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 210.00
1 ml x 10 mM (in DMSO)
$ 220.00
10 mg
$ 310.00
25 mg
$ 500.00
50 mg
$ 690.00
100 mg
$ 940.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry