β-Glu-PAB(CH2NH2)-Exatecan

SKU: orb3027496

Description

β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is an inhibitor of topoisomerase I. It binds to the topoisomerase I-DNA complex, preventing the re-ligation of DNA strands, leading to DNA breaks and apoptosis. In the tumor microenvironment, where β-glucuronidase is highly expressed, β-Glu-PAB(CH2NH2)-Exatecan is specifically cleaved to release Exatecan, which then exerts its cytotoxic effects. Additionally, β-Glu-PAB(CH2NH2)-Exatecan serves as an intermediate for the synthesis of Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan. This compound holds potential for cancer research.

Images & Validation

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Key Properties

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CAS Number	3025108-11-3
MW	790.74
Formula	C₃₉H₃₉FN₄O₁₃
SMILES	N(C(OCC1=CC(CN)=C(O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
Target	Topoisomerase

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Topoisomerase

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