Cart summary

You have no items in your shopping cart.

GNE-4997

SKU: orb1989245

Description

GNE-4997 is a highly potent and selective ITK inhibitor with a Ki of 0.09 nM. Its optimized basicity profile reduces off-target antiproliferative effects, lowering cytotoxicity. This compound is a valuable research tool for studying T-cell signaling in immunological and inflammatory disease models, both in vitro and in vivo.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1705602-02-3
MW515.58
FormulaC25H27F2N5O3S
SMILESC[C@@]12[C@@](C1(F)F)(CC3=C(C2)NN=C3C(NC4=CN([C@@H]([C@@]5(S(=O)(=O)CCCC5)[H])C6=CC=CC=C6)N=C4)=O)[H]
TargetOthers,Tyrosine Kinases

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

GNE-4997 (orb1989245)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%