Golimumab Antibody

SKU: orb1980732

Description

Golimumab is a humanized anti-TNFα monoclonal antibody with anti-inflammatory and anticancer properties. It inhibits pro-inflammatory cytokines like IL-6 and IL-1β, induces apoptosis, and is utilized in research models of rheumatoid arthritis, cartilage destruction, and oncology for both in vitro and in vivo studies.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	476181-74-5
MW	146.93 kDa
Purity	99.7% (SEC-HPLC)
Target	Caspase,Interleukin,TNF,Apoptosis

Bioactivity

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In Vivo

Golimumab (CNTO-148), administered intraperitoneally at doses of 1-10 mg/kg daily for 4 weeks in the Tg197 transgenic mouse model, relieves TNFα-induced arthritis in a mouse model of humans .Golimumab (CNTO-148), administered intravenously at a dose of 24 mg/kg daily for 7 days in Swiss-albino healthy male mice, inhibits oxidative stress, apoptotic cell death, and inflammatory response, thereby improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death .

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CNTO-148, MK-8259, SCH 900259, TNF-α

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Gene Symbol

Caspase,Interleukin,TNF,Apoptosis

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