GRGDSPK acetate

SKU: orb1737457

Description

GRGDSPK acetate is a synthetic peptide antagonist that inhibits integrin α5β1 binding to fibronectin. It is widely used in vitro and in vivo to study integrin roles in cellular adhesion, osteoblast function, and bone remodeling processes.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	144027-77-0
MW	775.81
Purity	97.90% (May vary between batches)
Formula	C₃₀H₅₃N₁₁O₁₃
SMILES	C(C)(O)=O.C([C@@H](NC([C@@H](NC(CNC([C@H](CCCNC(=N)N)NC(CN)=O)=O)=O)CC(O)=O)=O)CO)(=O)N1[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCC1
Target	Beta Amyloid
Solubility	DMSO:7.76 mg/mL (10 mM)

Bioactivity

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In Vitro

By measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats, we know that GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner. Treatment with GRGDSPK (10 and 50 μM; 4-day treatment) results in significant alterations in bone morphology, characterized by disruptions in the organization of osteoblasts and the mineralized matrix. In the presence of GRGDSPK peptide (RGD; 250 μM), added to the medium, the binding between integrins and fibronectin is effectively blocked, leading to a considerable increase in the average size of cell aggregates in wild-type cells. Addition of GRGDSPK (250 μM) leads to a significant reduction in adhesion forces and work exerted by wild-type mesendodermal progenitors, indicating the involvement of integrins expressed in these progenitors and the specificity of the detachment parameters recorded for fibronectin. GRGDSPK (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-modified peptides, at concentrations of 1.5 mM, 1.0 mM, and 0.5 mM, impair the fertilization ability of bovine oocytes by sperm cells, resulting in a dose-dependent reduction in cleavage rates.

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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BetaAmyloid, Beta Amyloid, bAmyloid, amyloid-β peptides, b Amyloid, GRGDSPK Acetate, GRGDSPK acetate(111119-28-9 Free base), βAmyloid, β Amyloid

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Compound Identifiers

PubChem CID

131698143 ↗

Key Properties

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No computed properties available.

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GRGDSPK acetate (orb1737457)

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GRGDSPK acetate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

GRGDSPK acetate (orb1737457)

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