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GSK-3β inhibitor 17

SKU: orb2646324

Description

This small molecule GSK-3β inhibitor, designated 17 (compound 5 n), demonstrates dose-dependent suppression of cisplatin-induced p-p65 and KIM-1 protein expression in HK-2 cells. At 32 µM, it also reduces mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1), highlighting its utility for in vitro research on acute kidney injury (AKI) and inflammatory signaling pathways.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2521624-67-7
MW617.58
FormulaC26H18F3N5O6S2
SMILESO=C(OC)C=1SC(=CC1)S(=O)(=O)NC=2C=CC(=CC2)C3=NC(=NO3)C=4C=CN=C(C4)NC5=CC=C(OC(F)(F)F)C=C5
TargetGSK-3

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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GSK-3β inhibitor 17 (orb2646324)

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