GSK-J4 Hydrochloride

SKU: orb1302901

Description

Research Area

Epigenetics & Chromatin

Images & Validation

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Key Properties

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CAS Number	1797983-09-5
MW	453.97
Purity	98.36%
Formula	C₂₄H₂₈ClN₅O₂
SMILES	Cl.CCOC(=O)CCNc1cc(nc(n1)-c1ccccn1)N1CCc2ccccc2CC1
Target	Histone Demethylase
Solubility	DMSO:50 mg/mL (110.14 mM);Ethanol:20 mg/mL (44.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.41 mM)

Bioactivity

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Target IC50	JMJD3 (cell-free assay):60 nM\|JMJD3:50 μM
In Vivo	Acting as a prodrug, GSK-J4 is rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which exhibits an IC50 value of 60 nM for the purified enzyme. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. Read more...
In Vitro	When administered to human primary macrophages, GSK-J4 can reduce LPS-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 μM). Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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1373423-53-0, 1373423-53-0 free base, cells, diabetic, demethylase, dendritic, H3K27me3/me2, GSK J4 HCl, GSK J4 HCl (1373423-53-0 free base), GSK J4 Hydrochloride, GSK-J4, GSKJ4 Hydrochloride, GSK-J4 Hydrochloride, GSK-J-4 Hydrochloride, HistoneDemethylase, Histone Demethylase, Inhibitor, JMJD3, inhibit, inflammation, mice, TGF-β, Th1, Th17

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Compound Identifiers

PubChem CID

71729974 ↗

Key Properties

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No computed properties available.

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