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GSK2982772

SKU: orb1300025

Description

GSK2982772 is a potent and selective RIPK1 inhibitor, demonstrating IC50 values of 16 nM (human) and 20 nM (monkey). This small molecule is a valuable research tool for investigating RIPK1-mediated necroptosis and inflammation in both cellular and animal models of inflammatory and neurodegenerative diseases.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1622848-92-3
MW377.4
Purity99.31% (May vary between batches)
FormulaC20H19N5O3
SMILESCN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O
TargetRIP kinase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.6 mM);DMSO:100 mg/mL (264.97 mM)

Bioactivity

Target IC50
RIP1 (human):16 nM|RIP1 (monkey):20 nM
In Vitro
GSK2982772 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking many TNF-dependent cellular responses. Highlighting its potential as a novel anti-inflammatory agent, the inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Receptor-interacting protein kinases, RIP kinase, RIP1, RIPK, RIPkinase, inhibit, Inhibitor, GSK2982772, GSK-2982772, GSK 2982772

Similar Products

  • GSK-2982772 [orb1226039]

    >98% (HPLC)

    1622848-92-3

    377.404

    C20H19N5O3

    500 mg, 200 mg, 25 mg, 50 mg, 100 mg, 1 g, 5 mg, 10 mg
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Key Properties

No computed properties available.

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GSK2982772 (orb1300025)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 170.00
5 mg
$ 190.00
10 mg
$ 280.00
25 mg
$ 440.00
50 mg
$ 590.00
100 mg
$ 780.00
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