Herpes Virus 8 Antibody

SKU: orb2644156

Description

HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. HHV 8 is the likely etiological agent of Kaposis sarcoma.

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Tested Applications	ELISA, IHC-P
Dilution Range	ELISA (order BSA-free format for coating),Immunohistochemistry (FFPE): 1-2ug/ml
Reactivity	Virus
Application Notes	Optimal dilution of the Herpes Virus 8 antibody should be determined by the researcher.

Key Properties

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Antibody Type	Primary Antibody
Host	Mouse
Clonality	Monoclonal
Isotype	Mouse IgG1, kappa
Clone No.	HHV8/3606
Immunogen	Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV8 was used as the immunogen for this Herpes Virus 8 antibody.
Purification	Protein G affinity chromatography
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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IHC staining of FFPE sarcoma with Herpes Virus 8 antibody (clone HHV8/3606). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free Herpes Virus 8 antibody (clone HHV8/3606) as confirmation of integrity and purity.

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Protocol Information

IHC-P

Immunohistochemistry Paraffin

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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