Hesperetin 7-O-glucoside

SKU: orb1297341

Description

Hesperetin 7-O-glucoside is a biosynthetic precursor to neohesperidin in C. aurantium. Research indicates it acts as an HMG-CoA reductase inhibitor, exhibits anti-Helicobacter pylori activity in vitro, and has demonstrated blood pressure-lowering effects in human clinical studies.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	31712-49-9
MW	464.42
Purity	98.10% (May vary between batches)
Formula	C₂₂H₂₄O₁₁
SMILES	COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2O1
Target	Interleukin,HMG-CoA Reductase,Antibacterial,Anti-infection
Solubility	DMSO:27.5 mg/mL (59.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.31 mM)

Bioactivity

−

In Vitro

Hesperetin 7-O-glucoside (Hes-7-G) was produced by the enzymatic conversion of hesperidin by Aspergillus sojae naringinase due to the removal of the terminal rhamnose.Extracts from orange juice and peel containing the hesperidin were so treated by this enzyme that the hesperidin could also be converted to Hesperetin 7-O-glucoside . The solubility of Hesperetin 7-O-glucoside in 10% ethanol was enhanced 55- and 88-fold over those of hesperidin and hesperetin, respectively, which may make Hesperetin 7-O-glucoside more bioavailable. Hesperetin 7-O-glucoside was 1.7- and 2.4-fold better than hesperidin and hesperetin, respectively, in the inhibition of human intestinal maltase. Hesperetin 7-O-glucoside was more potent by 2- and 4-fold than hesperidin in the inhibition of human HMG-CoA reductase. Additionally, Hesperetin 7-O-glucoside exhibited more effective inhibition of the growth of Helicobacter pylori than hesperetin, while its effectiveness was similar to that of hesperidin.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Bacterial, Antifection, antibacterial, Antihypertensive, Antiinfection, Anti-infection, inhibit, Inhibitor, enzymatic, Hesperetin 7 O glucoside, Hesperetin 7Oglucoside, Hesperetin 7-O-glucoside, Hesperidin, HMG-CoA Reductase (HMGCR), HMGCR, HMGCoAReductase, HMG-CoA Reductase, HMGCoA Reductase

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

147394 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols