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Hexyl gallate

SKU: orb1309577

Description

Hexyl gallate, the hexyl ester derivative of gallic acid, is a bioactive small molecule demonstrating potent in vitro antimalarial activity against Plasmodium falciparum with an IC50 of 0.11 mM. It serves as a valuable research tool for investigating novel antimalarial agents and studying parasite biochemistry.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number1087-26-9
MW254.28
Purity99.81%
FormulaC13H18O5
SMILESCCCCCCOC(=O)c1cc(O)c(O)c(O)c1
TargetParasite,Antibacterial
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.87 mM);DMSO:50 mg/mL (196.63 mM)

Bioactivity

Target IC50
Antimalarial:0.11 mM
In Vitro
Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) selectively inhibit RhlR-dependent production of rhamnolipid and pyocyanin, impacting only Rhl-regulated pathways while preserving elastase production and biofilm formation controlled by the Las system. These compounds show pigment inhibition at concentrations of 10-30 μM and exhibit notable antibacterial properties. Hexyl gallates also suppress N-butanoyl homoserine lactone (BHL) production at 100 and 300 μM, without affecting N-(3-oxododecanoyl)-l-homoserine lactone (OdDHL) and 2-heptyl-3-hydroxy-4(1H) quinolone (PQS) synthesis. As a promising antimicrobial alternative to copper compounds, Hexyl gallates effectively inhibit Xanthomonas citri growth at 30-50 μg/ml by targeting the bacterium's membrane, demonstrating a dose-responsive behavior.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

derivative, acid, Bacterial, antimalarial, antibacterial, Parasite, inhibit, Inhibitor, Hexyl 3,4,5-trihydroxybenzoate, Hexyl gallate, gallic, Gallic acid hexyl ester, rhamnolipid, pyocyanin
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Key Properties

No computed properties available.

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Hexyl gallate (orb1309577)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
25 mg
$ 80.00
50 mg
$ 90.00
100 mg
$ 110.00
200 mg
$ 150.00
500 mg
$ 230.00
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