HOMOPLANTAGININ

SKU: orb1302365

Description

Homoplantaginin, a flavonoid isolated from Salvia plebeia, demonstrates hepatoprotective properties and exhibits potent anti-influenza activity. Research applications include in vitro studies on hepatocyte injury models and investigations into its mechanism of viral inhibition.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	17680-84-1
MW	462.40
Purity	99.66%
Formula	C₂₂H₂₂O₁₁
SMILES	COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1
Target	NF-κB,TNF
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.00 mg/mL (8.65 mM);DMSO:100.00 mg/mL (216.26 mM)

Bioactivity

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In Vivo

Homoplantaginin displayed an antioxidant property in a cell-free system and showed IC(50) of reduction level of DPPH radical at 0.35 microg/ml. In human hepatocyte HL-7702 cells exposed to H(2)O(2), the addition of 0.1-100 microg/ml of Homoplantaginin, which did not have a toxic effect on cell viability, significantly reduced lactate dehydrogenase (LDH) leakage, and increased glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in supernatant. In vivo assay, we employed the model of Bacillus Calmette-Guérin (BCG)/lipopolysaccharide (LPS)-induced hepatic injury mice to evaluate efficacy of Homoplantaginin. Homoplantaginin (25-100mg/kg) significantly reduced the increase in serum alanine aminotranseferase (ALT) and aspartate aminotransferase (AST), decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1). The same treatment also reduced the content of thiobarbituric acid-reactive substances (TBARS), elevated the levels of GSH, GSH-Px and SOD in hepatic homogenate. The histopathological analysis showed that the grade of liver injury was ameliorated with reduction of inflammatory cells and necrosis of liver cells in Homoplantaginin treatment mice.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tumor Necrosis Factor Receptor, TNF-α, TNFR, TNF Receptor, NFkB, NF-kB, NF-κB, NFκB, Nuclear factor-κB, Nuclear factor-kappaB, inhibit, Inhibitor, p65, HOMOPLANTAGININ

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Compound Identifiers

PubChem CID

5318083 ↗

Key Properties

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No computed properties available.

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