Human Cadherin-17 / CDH17 Protein, Fc Tag

SKU: orb3123653

Description

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Images & Validation

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Application Notes	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 38.6 kDa. The protein migrates as 42-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Cadherin-17
Reactivity	Human
Tag	C-Fc
Molecular Weight	38.6 kDa
Expression Region	Ala 668 - Gly 777
Purity	95%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	20 mM Tris, 150 mM NaCl, pH 8.0
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Cadherin-17

RefSeq:Q12864

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	Q12864

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