Human FGF-10 / KGF 2 Protein, His Tag, Research Grade

SKU: orb3158144

Description

Fibroblast Growth Factor 10 (FGF 10) is an evolutionary conserved secreted growth factor mediating mostly mesenchymal to epithelial signaling. FGF 10 belongs to the FGF 7 subfamily and shares similar biochemical and amino acid sequences with its constituent members (FGF3, FGF 7 and FGF 22). As a paracrine FGF, FGF 10 elicits its biological responses by activating the fibroblast growth factor receptor 2b (FGF R 2b), is crucial for governing proximal distal outgrowth as well as patterning and acts upstream of the known apical ectodermal ridge (AER) marker FGF 8. FGF10 is also implicated in pancreatic cancer, and that overexpression of FGFR2b is associated with metastatic invasion.

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 21.3 kDa. The protein migrates as 25-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Key Properties

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Expression System	E. coli
Target	FGF-10
Reactivity	Human
Tag	N-10×His
Molecular Weight	21.3 kDa
Expression Region	Gln 38 - Ser 208
Purity	95%
Endotoxins	0.01 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	PBS, 0.2 M Arginine, pH 7.4
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

FGF-10

RefSeq:O15520

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	O15520

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