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Isoangustone A

SKU: orb1682376

Description

Isoangustone A is a cell-permeable natural product that acts as an ATP-competitive inhibitor of PI3K, MKK4, and MKK7. It suppresses G1/S phase progression and Akt/GSK-3β/JNK signaling, demonstrating anti-proliferative effects in human melanoma cells in vitro and reducing tumor growth in mouse xenograft models in vivo.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number129280-34-8
MW422.47
Purity98.89%
FormulaC25H26O6
SMILESO=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C
TargetAutophagy,JNK,MAPK,PI3K,Apoptosis

Bioactivity

In Vivo
Method: A SK-MEL-28 xenograft tumor model was established using male Balb/c nude (nu/nu) mice. Mice were administered Isoangustone A via daily intraperitoneal injection at doses of 2 or 10 mg/kg for 35 consecutive days to evaluate its antitumor effects. Result: Isoangustone A significantly reduced tumor weight compared to the control group. It also markedly decreased the expression of proliferating cell nuclear antigen (PCNA) and reduced the phosphorylation levels of Akt.
In Vitro
Method: A cell proliferation assay was performed using the SK-MEL-28 cell line. Cells were treated with Isoangustone A at concentrations of 10 μM and 20 μM for 48 and 72 hours to evaluate its effect on cell proliferation. Result: Isoangustone A significantly inhibited the proliferation of SK-MEL-28 cells in a dose- and time-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NFκB, NF-κB, NFkB, NF-kB, MMP, Isoangustone A, JNK, GSK3, GSK-3, Akt, CDK, TGF-β/Smad, ROS, PI3K
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Key Properties

No computed properties available.

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Isoangustone A (orb1682376)

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1 mg
$ 270.00
5 mg
$ 620.00
10 mg
$ 870.00
25 mg
$ 1,270.00
50 mg
$ 1,720.00
DispatchUsually dispatched within 5-10 working days
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