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Isoforskolin

SKU: orb1297414

Description

Isoforskolin, a compound derived from Coleus forskohlii, suppresses the release of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 in human mononuclear leukocytes. This activity supports its research application in studying inflammatory conditions such as Lyme arthritis, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number64657-21-2
MW410.50
Purity99.87% (May vary between batches)
FormulaC22H34O7
SMILES[H][C@@]12[C@H](OC(C)=O)[C@H](O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
TargetIL Receptor,Interleukin,TNF
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.00 mg/mL (2.44 mM);DMSO:2.10 mg/mL (5.12 mM)

Bioactivity

In Vivo
Isoforskolin downregulats the transcription and expression of TNF-α and IL-6 induced by rBmpA in mice. Isoforskolin inhibits the symptoms of experimental Lyme arthritis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Coleonol B, IL Receptor, ILReceptor, IL-6, IL-8, IL-1β, Isoforskolin, TNF-α

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Key Properties

No computed properties available.

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Isoforskolin (orb1297414)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 190.00
10 mg
$ 260.00
25 mg
$ 410.00
50 mg
$ 580.00
100 mg
$ 810.00
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