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IU1-248

SKU: orb1298140

Description

IU1-248 is a potent and selective small molecule inhibitor of the deubiquitinase USP14, exhibiting an IC50 of 0.83 µM. This compound is a valuable research tool for probing proteasome function and protein homeostasis in cellular and biochemical studies, with applications in neurodegeneration and oncology research.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2307472-03-1
MW337.42
Purity99.30%
FormulaC20H23N3O2
SMILESCc1cc(C(=O)CN2CCC(O)CC2)c(C)n1-c1ccc(cc1)C#N
TargetDUB
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.78 mM);DMSO:80 mg/mL (237.09 mM)

Bioactivity

Target IC50
USP14:0.83 μM
In Vitro
IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is 10-fold more potent than that of IU1 (IC50=12.25 μM).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Deubiquitinase, DUBs, Inhibitor, inhibit, IU1 248, IU1248, IU-1-248, IU1-248, USP14
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Key Properties

No computed properties available.

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Protocol Information

IU1-248 (orb1298140)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 220.00
25 mg
$ 400.00
50 mg
$ 540.00
100 mg
$ 740.00
200 mg
$ 1,020.00
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