Jolkinolide B

SKU: orb1304677

Description

Jolkinolide B is a bioactive diterpenoid isolated from Euphorbia fischeriana roots, known for inducing apoptosis in various cancer cell lines. Its application extends to research on osteolysis prevention, with studies demonstrating efficacy in both in vitro cellular models and in vivo bone resorption assays.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	37905-08-1
MW	330.42
Purity	99.70% (May vary between batches)
Formula	C₂₀H₂₆O₄
SMILES	[H][C@]12CC[C@@]34O[C@@H]3C3=C(C)C(=O)O[C@]33O[C@@H]3[C@@]4([H])[C@]1(C)CCCC2(C)C
Target	JNK,Akt,TNF,PI3K,Bcl-2 Family,JAK,mTOR,STAT,ERK,IL Receptor,p38 MAPK,NF-κB,Apoptosis,Caspase
Solubility	DMSO:3.31 mg/mL (10.02 mM)

Bioactivity

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In Vitro

Jolkinolide B has potent anti-inflammatory, and antitumor activities. Jolkinolide B is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) without cytotoxicity. Furthermore, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K (CtsK), and calcitonin receptor (CTR), was significantly inhibited. Jolkinolide Binhibited RANKL-induced activation of NF-ÎºB by suppressing RANKL-mediated IÎºBα degradation. Moreover, Jolkinolide B inhibited RANKL-induced phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK).

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, JAK, JNK, Jolkinolide B, ILReceptor, mTOR, NF-κB, NFκB, NF-kB, NFkB, leukemic, IL Receptor, Inhibitor, ERK, human, cells, Caspase, Bcl-2, cancer, Apoptosis, Akt, STAT, TNF-α, p38MAPK, p38 MAPK, PI3K, U937

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Compound Identifiers

PubChem CID

161954 ↗

Key Properties

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No computed properties available.

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Jolkinolide B

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

Jolkinolide B (orb1304677)

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