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JZL195

SKU: orb1223389

Description

JZL195 is a potent and selective dual inhibitor of FAAH and monacylglycerol lipase (MAGL). JZL195 has greater anti-allodynic efficacy than selective FAAH, or MAGL inhibitors, plus a greater therapeutic window than a cannabinoid receptor agonist. JZL195 may have greater potential in alleviating neuropathic pain, compared to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists.

Images & Validation

Key Properties

CAS Number1210004-12-8
MW433.46
Purity>98% (HPLC)
FormulaC24H23N3O5
SMILES[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cc(Oc4ccccc4)ccc3)CC2)cc1
TargetFAAH| MAGL
SolubilityDMSO : ≥ 42 mg/mL. 96.89 mM

Bioactivity

In Vivo
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal model: Male C57BL/6J mice. Dosage: 20 mg/kg. Administration: Intraperitoneal injection. Result: Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
In Vitro
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively). JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JZL195 | JZL-195 | JZL 195

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    99.81%

    1210004-12-8

    433.46

    C24H23N3O5

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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JZL195 (orb1223389)

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200 mg
500 mg
5 mg
$ 80.00
10 mg
$ 120.00
25 mg
$ 210.00
50 mg
$ 370.00
100 mg
$ 540.00