K-7174 dihydrochloride

SKU: orb1709351

Description

K-7174 dihydrochloride is a dual proteasome and GATA inhibitor. It has been shown to induce apoptosis and protect against neuronal degeneration in research models, making it a useful compound for studying neuroprotection and cell death mechanisms in vitro and in vivo.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	191089-60-8
MW	641.67
Purity	99.15%
Formula	C₃₃H₅₀Cl₂N₂O₆
SMILES	Cl.Cl.COc1cc(\C=C\CCCN2CCCN(CCC\C=C\c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC
Target	Apoptosis,Proteasome
Solubility	H2O:15 mg/mL (23.38 mM)

Bioactivity

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In Vivo	In ICR mice injected with IL-β or TNF-α, K-7174 dihydrochloride (30 mg/kg; intraperitoneal injection; once daily for 9 days) increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations. Read more...
In Vitro	In KMS12-BM, U266, and RPMI8226 cell lines, K-7174 dihydrochloride (0-25 μM; 72 hours) inhibited the growth of multiple myeloma cells.

Storage & Handling

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Storage	store at low temperature,keep away from moisture,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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K7174, K-7174, K7174 2HCl, K-7174 2HCl, K-7174 Dihydrochloride, K 7174, K 7174 2HCl, proteasome

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Compound Identifiers

PubChem CID

9874190 ↗

Key Properties

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No computed properties available.

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