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Karanjin

SKU: orb1217931

Description

Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.

Images & Validation

Key Properties

CAS Number521-88-0
MW292.29
Purity>98% (HPLC)
FormulaC18H12O4
SMILESO=C1C(OC)=C(C2=CC=CC=C2)OC3=C1C=CC4=C3C=CO4
TargetAMPK
SolubilityDMSO:10 mM

Bioactivity

In Vivo
Animal model: Streptozotocin-induced diabetic rats. Dosage: 50, 100 mg/kg. Administration: Oral gavage (p.o.), wait for 6h. Result: Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage. Animal model: Adjuvant induced arthritis model (AIA) Wistar strain male albino rats. Dosage: 10, 20 mg/kg/d. Administration: Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination. Result: Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly. Animal model: Diazepam-induced male swiss albino mice. Dosage: 25, 50 mg/kg/d. Administration: Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d. Result: Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.
In Vitro
Cell Cycle Analysis Cell line: A549, HL-60. Concentration: 4, 6, 8 μM for A549, 2, 4, 6 μM for HL-60. Incubation time: 72 h. Result: Blocked the cell cycle markedly at G2/M phase of A549 (> 60% for 8 μM) and HL-60 (> 40% for 6 μM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Karanjin (orb1217931)

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Available Sizes

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200 mg
500 mg
5 mg
$ 150.00
10 mg
$ 230.00
25 mg
$ 370.00
50 mg
$ 530.00
100 mg
$ 760.00