Ketoprofen

SKU: orb1310246

Description

Ketoprofen is a propionic acid-derived NSAID that exerts anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase (COX) I and II enzymes, thereby reducing prostaglandin and thromboxane synthesis. It is widely used in research models of inflammation and pain, both in vitro and in vivo, to study COX pathway inhibition and platelet aggregation.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Images & Validation

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Key Properties

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CAS Number	22071-15-4
MW	254.28
Purity	>99.99% (May vary between batches)
Formula	C₁₆H₁₄O₃
SMILES	CC(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1
Target	Apoptosis,COX,MRP
Solubility	DMSO:250 mg/mL (983.17 mM);Ethanol:48 mg/mL (188.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.87 mM)

Bioactivity

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Target IC50	COX-2:26 nM\|COX-1:2 nM
In Vivo	Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. Read more...
In Vitro	Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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obesity, MRAP4, inhibit, Ketoprofen, Inhibitor, HFD-induced obese mice, Apoptosis, Anti-inflammatory agents, 3T3-L1 cell, COX, COX inhibitor, COX-1, COX-2, Cyclooxygenase, RP19583, RP-19583, RP 19583, white adipocytes

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Compound Identifiers

PubChem CID

3825 ↗

Key Properties

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No computed properties available.

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Ketoprofen (orb1310246)

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CAS Number:	57495-14-4
MW:	277.27
Formula:	C₁₆H₁₄NaO₃

MW:	257.3
Formula:	C₁₆H₁₁D₃O₃

CAS Number:	56105-81-8
MW:	254.28
Formula:	C₁₆H₁₄O₃

CAS Number:	57469-78-0
MW:	400.48
Formula:	C₂₂H₂₈N₂O₅

Ketoprofen

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Ketoprofen (orb1310246)

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