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Kigamicin C

SKU: orb1692537

Description

Kigamicins are antitumor antibiotics with selective cytotoxicity against nutrient-starved pancreatic cancer cells, such as PANC-1, and exhibit antimicrobial activity against Gram-positive bacteria. Kigamicin D demonstrates in vivo efficacy by suppressing pancreatic tumor growth in mouse models, potentially through inhibition of Akt activation under nutrient stress. These compounds also induce necrosis in human myeloma cells while sparing normal lymphocytes.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number680571-51-1
MW809.818
FormulaC41H47NO16
SMILES[H][C@]12Cc3cc4C[C@@]5(C)OCCN5C(=O)c4c(O)c3-c3c(O)c4c(oc5[C@@H](O)[C@@H](C[C@H](O)c5c4=O)O[C@H]4CC[C@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@@H](C)O5)[C@@H](C)O4)c(OCO1)c23
TargetAntibiotic,Others,Antibacterial

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Kigamicin C (orb1692537)

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