KL1333 hydrochloride

SKU: orb3135476

Description

KL1333 hydrochloride is an orally effective NAD+ modulator that acts as a substrate for NAD(P)H: quinone oxidoreductase 1 (NQO1), leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ subsequently activates SIRT1 and AMPK, which in turn activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in fibroblasts of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). It also has a protective effect against cisplatin-induced ototoxicity in cultured mouse cochlea.

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Key Properties

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CAS Number	1800406-26-1
MW	276.72
Formula	C₁₄H₁₃ClN₂O₂
SMILES	Cl.O=C1C(=O)C=2C=CC=CC2C=3NC(=NC13)C(C)C
Target	Mitochondrial Metabolism,Reductase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Mitochondrial Metabolism,Reductase

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