L-Palmitoylcarnitine

SKU: orb1989213

Description

L-Palmitoylcarnitine (L-PC) is a naturally occurring fatty acid derivative that acts as an endogenous Na+/K+-ATPase inhibitor and enhances the activity of fibrinolytic enzymes, including tPA, to suppress thrombus formation. It is utilized in cardiovascular and metabolic research, particularly in studies investigating thrombosis, ischemia-reperfusion injury, and cellular energy metabolism in both in vitro and in vivo models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2364-67-2
MW	399.61
Purity	99.81%
Formula	C₂₃H₄₅NO₄
SMILES	[C@H](OC(CCCCCCCCCCCCCCC)=O)(C[N+](C)(C)C)CC([O-])=O
Target	ATPase,Endogenous Metabolite,Potassium Channel
Solubility	Ethanol:25 mg/mL (62.56 mM)

Bioactivity

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In Vitro

METHODS: We investigated whether L-Palmitoylcarnitine (1 μM) modulates K(ATP) channel activity in inside-out patches of guinea pig ventricular myocytes by altering the membrane lipid environment. RESULTS: L-Palmitoylcarnitine (1 μM) inhibited KATP channel activity by interacting with Kir6.2 without affecting single-channel conductance; L-Palmitoylcarnitine also enhanced the ATP sensitivity of the channel, decreasing the IC50 from 62.0±2.7 to 30.3±5.5 μM.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Human Endogenous Metabolite, L Palmitoylcarnitine, Na+/K+-ATPase, LPalmitoylcarnitine, L-Palmitoylcarnitine, Palmitoyl-L-carnitine

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Compound Identifiers

PubChem CID

11953816 ↗

Key Properties

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No computed properties available.

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