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L6H21

SKU: orb1739854

Description

L6H21 is a small molecule inhibitor targeting MD-2, useful for investigating neuroinflammatory pathways. It serves as a research tool in studies of cognitive deficits and neuronal injury, applicable in both in vitro cellular assays and in vivo models of brain damage.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction

Images & Validation

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L6H21

Key Properties

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CAS Number24533-47-9
MW298.33
Purity99.26% (May vary between batches)
FormulaC18H18O4
SMILESO(C)C1=C(/C=C/C(=O)C2=CC=C(OC)C=C2)C=CC=C1OC
TargetInterleukin,TNF,ROS,Bcl-2 Family,Reactive Oxygen Species,NOD-like Receptor (NLR),NF-κB,Apoptosis,Caspase,TLR
SolubilityDMSO:80 mg/mL (268.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.06 mM)

Bioactivity

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Target IC50
IL-6:8.59 μM
In Vivo
A group of mice was treated with L6H21 via oral gavage at a dose of 10 mg/kg/d on the same day as the start of alcohol feeding. L6H21 treatment significantly decreased inflammation in liver tissue induced by EtOH + LPS. LPS aggravated EtOH-induced hepatic steatosis and liver injury, which was improved with L6H21 pretreatment. L6H21 treatment plays an important role in the inhibition of EtOH + LPS-induced inflammasome activation in the liver.
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In Vitro
The cells were exposed to ethanol (EtOH; 100 mmol/l) for 48 hours prior to the treatment with LPS at 500 ng/ml for 6 hours. L6H21 was administered (10 or 20 μmol/l) 2 hours before EtOH treatment. L6H21 protects against oxidative stress and apoptosis induced by EtOH and/or LPS in RAW264.7 cells.
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Storage & Handling

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Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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TNF Receptor, TLR, NF-κB, NFκB, NF-kB, NFkB, L6H21, L6H-21, ALN29882, ALN-29882, ALN 29882, 1-2-dioleoyl-sn-glycerol

Similar Products

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  • L6H21

    L6H21 [orb2900591]

    >98% (HPLC)

    24533-47-9

    298.33

    C18H18O4

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 2 mg
Quality Guarantee

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Compound Identifiers

PubChem CID
5346378 ↗

Key Properties

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No computed properties available.

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L6H21 (orb1739854)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 110.00
10 mg
$ 150.00
25 mg
$ 280.00
50 mg
$ 430.00
100 mg
$ 670.00
DispatchUsually dispatched within 6-8 weeks
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