Lapaquistat acetate

SKU: orb1707099

Description

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor investigated for hypercholesterolemia research. It demonstrates anti-inflammatory properties and has been shown in vitro to reduce statin-induced toxicity in human muscle cells, as well as in vivo to protect guinea pigs from simvastatin-induced myotoxicity.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	189060-13-7
MW	645.14
Purity	>99.99% (May vary between batches)
Formula	C₃₃H₄₁ClN₂O₉
SMILES	O(C)C1=C([C@@H]2C=3C(N(CC(COC(C)=O)(C)C)C(=O)[C@@H](CC(=O)N4CCC(CC(O)=O)CC4)O2)=CC=C(Cl)C3)C=CC=C1OC
Target	Transferase,Others
Solubility	DMSO:1 mg/mL (1.55 mM)

Bioactivity

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In Vivo	Lapaquistat acetate (100 or 200 mg/kg/ day) for 32 weeks increased collagen concentration and transformed coronary plaque into fibromuscular plaque in male WHHLMI rabbits. Read more...
In Vitro	Lapaquistat acetate (0-1000 nmol/L,24h) inhibited LPS-stimulated IL-1β production in MKD-like THP-1 cells.

Storage & Handling

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Storage	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TAK475, TAK-475, TAK 475, Squalene synthase

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Compound Identifiers

PubChem CID

9874248 ↗

Key Properties

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No computed properties available.

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