LDN-193189 Tetrahydrochloride

SKU: orb1686141

Description

LDN-193189 Tetrahydrochloride is a potent and selective BMP type I receptor inhibitor, primarily targeting ALK2 and ALK3. It is widely used in biochemical and cellular research to study BMP signaling pathways, including in vitro assays and in vivo models related to bone disorders like fibrodysplasia ossificans progressiva (FOP).

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	2310134-98-4
MW	552.33
Purity	98.21%
Formula	C₂₅H₂₆Cl₄N₆
SMILES	C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl.Cl.Cl
Target	ALK,TGF-beta/Smad
Solubility	H2O:25 mg/mL (45.26 mM);DMSO:3.3 mg/mL (5.97 mM)

Bioactivity

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Target IC50	BMPR1A:7 nM\|ACVR1:5 nM
In Vivo	Methods: SCID mice bearing MDA-PCa-118b tumor xenografts were treated with LDN-193189 Tetrahydrochloride (3 mg/kg, intraperitoneal injection, twice daily). Tumor size and body weight were measured weekly to investigate the effect of LDN-193189 Tetrahydrochloride on tumor growth in vivo. Results: Treatment of MDA-PCa-118b tumor-bearing mice with LDN-193189 Tetrahydrochloride resulted in decreased bone formation and attenuated tumor growth. Read more...
In Vitro	LDN-193189 Tetrahydrochloride potently inhibits the kinase activity of ALK4 and ActRIIA with IC50 values of 101 and 210 nM, respectively.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DM3189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, LDN193189 Tetrahydrochloride

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Compound Identifiers

PubChem CID

66576997 ↗

Key Properties

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No computed properties available.

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