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LE01 Antibody

SKU: orb2803453

Description

LE01 is a drug-linker conjugate for antibody-drug conjugates (ADCs), consisting of a cleavable linker and the topoisomerase I inhibitor payload DXd. It is utilized in constructing the HER2-targeting ADC HER2-LE01 for research into targeted cancer therapies, with applications in both in vitro and in vivo experimental models.

Research Area

Molecular Biology

Images & Validation

Key Properties

CAS Number2718125-83-6
MW1105.13
FormulaC55H61FN10O14
SMILESN(C(COC(N(CCNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)C)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
TargetDrug-Linker Conjugates for ADC,Topoisomerase

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

LE01 Antibody (orb2803453)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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