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Licochalcone B

SKU: orb1222001

Description

Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. LCB and Licochalcone D(LCD) significantly reduced the LPS-induced production of NO, TNFalpha and MCP-1. A novel LCB derivative compound: (E)-3-(3, 4-dihydroxy-2-methoxyphenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock.

Images & Validation

Key Properties

CAS Number58749-23-8
MW286.28
Purity>98% (HPLC)
FormulaC16H14O5
SMILESCOC1=C(C=CC(=C1O)O)C=CC(=O)C2=CC=C(C=C2)O
TargetOthers
SolubilityIn Vitro: DMSO : 83.33 mg/mL (291.08 mM)

Bioactivity

In Vivo
Animal model: Mice induced by CCl4. Dosage: 1, 5, 25 mg/kg. Administration: Oral gavage. Result: Elevated the levels of SOD and GSH, and reduced the GSSG levels.
In Vitro
Western blot analysis. Cell line: RAW264.7 cells Concentration: 10 μM. Incubation time: 1 h. Result: Inhibited the phosphorylation of NF-κB at serine 276 but not at serine 536.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Licochalcone B | Licochalcone-B

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    99.93% (May vary between batches)

    58749-23-8

    286.28

    C16H14O5

    1 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 ml x 10 mM (in DMSO), 5 mg
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Licochalcone B (orb1222001)

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Available Sizes

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 290.00
25 mg
$ 480.00
50 mg
$ 690.00
100 mg
$ 980.00