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LSP-249

SKU: orb1309467

Description

LSP-249 is a potent small molecule inhibitor of plasma kallikrein, exhibiting an EC50 below 100 nM in cellular assays. It is a valuable research tool for investigating hereditary angioedema (HAE) pathophysiology and for preclinical in vitro and in vivo studies targeting kallikrein-mediated pathways.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number1801253-04-2
MW431.92
Purity99.27% (May vary between batches)
FormulaC24H22ClN5O
SMILESCc1cc(N)nc(C)c1CNC(=O)c1ccnc(Cc2ccc3ncc(Cl)cc3c2)c1
TargetOthers,Serine Protease
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.63 mM);DMSO:31.25 mg/mL (72.35 mM)

Bioactivity

Target IC50
Kallikrein:< 100 nM (EC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

angioedema, LSP 249, LSP249, LSP-249, Inhibitor, kallikrein, kallikrein in cell, inhibit, Threonine proteases, Serine proteases, Ser/Thr Protease, Serine endopeptidases

Similar Products

  • LSP-249 [orb1218603]

    >98% (HPLC)

    1801253-04-2

    431.92

    C24H22ClN5O

    100 mg, 1 g, 50 mg, 200 mg, 500 mg, 2 mg, 5 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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Protocol Information

LSP-249 (orb1309467)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 370.00
100 mg
$ 580.00
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