Cart summary

You have no items in your shopping cart.

Lys-SMCC-DM1

SKU: orb1309457

Description

Lys-SMCC-DM1 is an antibody-drug conjugate (ADC) designed to target HER2, delivering the potent microtubule-disrupting agent DM1. It is widely utilized in breast cancer research for investigating ADC mechanisms and efficacy in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1281816-04-3
MW1103.71
Purity≥98% (May vary between batches)
FormulaC53H75ClN6O15S
SMILESC[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS[C@@H]5C(=O)N(C[C@@H]6CC[C@@H](C(NCCCC[C@@H](C(O)=O)N)=O)CC6)C(=O)C5)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
TargetDrug-Linker Conjugates for ADC,Microtubule Associated
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.81 mM);DMSO:60 mg/mL (54.36 mM)

Bioactivity

In Vitro
METHODS: Lys-SMCC-DM1, DXd (1), and DXd (2) were simultaneously subjected to parallel artificial membrane permeability assay (PAMPA) using the Lys-SMCC-DM1 Freedom EVO200 system. RESULTS: Lys-SMCC-DM1 has low permeability. METHODS: MDCKII/SLC46A3 dC cells were treated with Lys-SMCC-DM1 (5 µM) for 30 min, and a cellular uptake assay was performed to verify whether SLC46A3 directly transported Lys-SMCC-DM1. RESULTS: SLC46A3 directly recognized and transported Lys-SMCC-DM1 and mediated the cytotoxic effects of T-DM1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Lys-Nε-MCC-DM1, LysSMCCDM1, Lys-SMCC-DM1, Lys-SMCC-DM-1, Lys SMCC DM1, Microtubule Associated, MicrotubuleAssociated, linker-payload, inhibit, Maytansinoids, HER2, Inhibitor, growth inhibitory, Drug-Linker Conjugates for ADC, DrugLinker Conjugates for ADC, DrugLinkerConjugatesforADC, tubulin polymerization, tubulin

Similar Products

  • (Rac)-Lys-SMCC-DM1 [orb2564851]

    1103.71

    C53H75ClN6O15S

    50 mg, 10 mg
  • Lys-SMCC-DM1 [orb1218966]

    >98% (HPLC)

    1281816-04-3

    1103.7

    C53H75ClN6O15S

    1 g, 500 mg, 200 mg, 100 mg, 25 mg, 10 mg, 5 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Lys-SMCC-DM1 (orb1309457)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 330.00
5 mg
$ 740.00
10 mg
$ 1,040.00
1 ml x 10 mM (in DMSO)
$ 1,230.00
25 mg
$ 1,520.00