MAC glucuronide phenol-linked SN-38

SKU: orb1987862

Description

This compound, a pH-sensitive prodrug linker conjugate of SN-38, acts as a DNA topoisomerase I inhibitor. It demonstrates cytotoxic activity in vitro, with IC50 values of 113 ng/mL in L540cy cells and 67 ng/mL in Ramos cells. Its design is relevant for developing antibody-drug conjugates (ADCs) in oncology research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2246380-69-6
MW	1091.06
Formula	C₅₀H₅₄N₆O₂₀S
SMILES	CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCN(CCS(C)(=O)=O)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(NC(=O)CN(C)C(=O)CCN4C(=O)C=CC4=O)c3)cc12
Target	Drug-Linker Conjugates for ADC,PROTAC Linker

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

139035092 ↗

Key Properties

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No computed properties available.

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