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MC-GGFG-DX8951

SKU: orb1989101

Description

MC-GGFG-DX8951 is an antibody-drug conjugate (ADC) featuring the potent topoisomerase I inhibitor DX8951 linked via a cleavable GGFG peptide. This conjugate is designed for targeted cancer therapy research and has demonstrated antitumor activity in both in vitro and in vivo preclinical studies.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1600418-29-8
MW946.98
Purity99.04% (May vary between batches)
FormulaC49H51FN8O11
SMILESN(C(CNC([C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(=O)C=CC2=O)=O)=O)=O)=O)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
TargetDrug-Linker Conjugates for ADC,PROTAC-Linker Conjugates for PAC,Topoisomerase
SolubilityDMSO:40 mg/mL (42.24 mM)

Bioactivity

In Vivo
MC-GGFG-DX8951 has properties such as stability in blood circulation, specific release in tumor tissue, and minimal toxicity to normal tissues .
In Vitro
MC-GGFG-DX8951 is linked to an antibody through a protease-cleavable MC-GGFG linker for targeted delivery.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Camptothecins, DrugLinker Conjugates for ADC, DrugLinkerConjugatesforADC, MC GGFG DX8951, MC-GGFG-DX 8951, MCGGFGDX8951, MC-GGFG-DX8951, MC-GGFG-DX-8951, MC-GGFG-Exatecan
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Key Properties

No computed properties available.

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Protocol Information

MC-GGFG-DX8951 (orb1989101)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 160.00
5 mg
$ 320.00
10 mg
$ 490.00
25 mg
$ 940.00
50 mg
$ 1,490.00
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